Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049167 | FEBS Letters | 2010 | 8 Pages |
Abstract
The SOD1-G93A transgenic mouse is a widely used ALS model, but the death of lower motor neurons is the hallmark. Here, we show that the SOD1-G93A transgene and HO-1 are preferentially over-expressed in the lumbar spinal cord, particularly in the activated astrocytes of the transgenic mice. We also show down-regulation of GLT-1 in spite of the proliferating astrocytes. However, GLT-1, SOD1-G93A transgene and HO-1 expression were not obviously changed in the motor cortex. Our data link spinal cord vulnerability to relatively decreased expression of GLT-1, and high expression of the transgene and HO-1 in astrocytes in SOD1-G93A transgenic mice.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Yansu Guo, Weisong Duan, Zhongyao Li, Jing Huang, Yunxia Yin, Kunxi Zhang, Qian Wang, Zhifang Zhang, Chunyan Li,