Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049168 | FEBS Letters | 2010 | 5 Pages |
Abstract
Here we report a thorough analysis of cross-predictions between coiled-coil and disordered protein segments using various prediction algorithms for both sequence classes. Coiled-coils are often predicted to be unstructured, consistent with their obligate multimeric nature, whereas reverse cross-predictions are rare due to the regularity of coiled-coil sequences. We propose the simultaneous use of the programs Coils and IUPred to achieve acceptable prediction accuracy and minimize the extent of cross-predictions. The relevance of observed cross-predictions might be that disordered sequences can adopt coiled-coil conformation relatively easily during protein evolution.
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Authors
Balázs Szappanos, Dániel Süveges, László Nyitray, András Perczel, Zoltán Gáspári,