Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049377 | FEBS Letters | 2009 | 7 Pages |
Abstract
Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy.
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Authors
Elisabetta Straface, Rosa Vona, Lucrezia Gambardella, Barbara Ascione, Maria Marino, Paola Bulzomi, Silvia Canu, Rita Coinu, Giuseppe Rosano, Walter Malorni, Flavia Franconi,