Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049445 | FEBS Letters | 2007 | 6 Pages |
Abstract
Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.
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Authors
Masayuki Kaneko, Saori Yasui, Yoshifumi Niinuma, Kiho Arai, Tomohiro Omura, Yasunobu Okuma, Yasuyuki Nomura,