| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2049560 | FEBS Letters | 2007 | 5 Pages |
Abstract
Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with α-tocopheryl succinate (α-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that α-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling.
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Authors
Jiri Neuzil, Emma Swettenham, Xiu-Fang Wang, Lan-Feng Dong, Michael Stapelberg,