Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049602 | FEBS Letters | 2009 | 9 Pages |
Abstract
Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic repertoire of the organism is as broad and deep as it was in the pre-genomic era. There are two fundamental unsolved problems that provide the context for the challenges in relating genotype to phenotype. We address one of these and describe a generic method for constructing a system design space in which qualitatively distinct phenotypes can be identified and counted, their relative fitness analyzed and compared, and their tolerance to change measured.
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Authors
Michael A. Savageau, Rick A. Fasani,