Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049740 | FEBS Letters | 2008 | 7 Pages |
Abstract
PTPRO is often silenced by DNA hypermethylation in primary human tumors and cancer cell lines and functions as a tumor suppressor. Here we show that PTPRO is a target of E2F1. In addition, the microRNA cluster miR-17-92, another target of E2F1, participates in PTPRO regulation. PTPRO mRNA was up-regulated during S phase in synchronized HeLa cells and in vitro PTPRO promoter activity is high in early S phase while the PTPRO 3′UTR reporter activity is low in late S phase. This study provides evidence that the PTPRO gene is co-regulated by both E2F1 and miR-17-92.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Xin Xu, Yan Hong, Chenfei Kong, Liang Xu, Jiang Tan, Qian Liang, Baiqu Huang, Jun Lu,