Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049841 | FEBS Letters | 2008 | 8 Pages |
Abstract
Although mitochondria have been the object of intensive study over many decades, some aspects of their metabolism remain to be fully elucidated, including the l-lactate metabolism.We review here the novel insights arisen from investigations on l-lactate metabolism in mammalian, plant and yeast mitochondria. The presence of l-lactate dehydrogenases inside mitochondria, where l-lactate enters in a carrier-mediated fashion, suggests that mitochondria play an important role in l-lactate metabolism. Functional studies have demonstrated the occurrence of several l-lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria.
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Authors
Salvatore Passarella, Lidia de Bari, Daniela Valenti, Roberto Pizzuto, Gianluca Paventi, Anna Atlante,