Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049843 | FEBS Letters | 2008 | 5 Pages |
Abstract
The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30–40 nm diameter with a scaffold-like arrangement of protein subunits at the surface. The ‘PspA-scaffold’ is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
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Authors
Kerstin Standar, Denise Mehner, Hendrik Osadnik, Felix Berthelmann, Gerd Hause, Heinrich Lünsdorf, Thomas Brüser,