| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2049987 | FEBS Letters | 2009 | 7 Pages |
Abstract
Available data suggest that a copper-and zinc-containing dismutase (CuZnSOD) plays a significant role in protecting eukaryotic cells against oxidative modifications which may contribute to cell aging. Here we demonstrated that depletion of CuZnSOD in Saccharomyces cerevisiae cells (Δsod1 cells) affected distinctly channel activity of VDAC (voltage dependent anion selective channel) and resulted in a moderate reduction in VDAC levels as well as in levels of protein crucial for VDAC import into mitochondria, namely Tob55/Sam50 and Tom40. The observed alterations may result in mitochondriopathy and subsequently in the shortening of the replicative life span observed for S. cerevisiaeΔsod1 cells.
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Authors
Andonis Karachitos, Hanna Galganska, Malgorzata Wojtkowska, Malgorzata Budzinska, Olgierd Stobienia, Grzegorz Bartosz, Hanna Kmita,