Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2049990 | FEBS Letters | 2009 | 5 Pages |
Abstract
In this study, we demonstrated effects of acetyl-l-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-α (TNF-α) in rat L6 cells. TNF-α downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-α-induced insulin resistance through AMPK pathway in skeletal muscle cells.
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Authors
Zhaofeng Zhang, Ming Zhao, Qiong Li, Haifeng Zhao, Junbo Wang, Yong Li,