Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050004 | FEBS Letters | 2008 | 7 Pages |
Abstract
Type 2 diabetes mellitus (DM) and Alzheimer’s disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation – amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ.
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Authors
Yun-An Lim, Lars M. Ittner, Yun Li Lim, Jürgen Götz,