Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050138 | FEBS Letters | 2007 | 5 Pages |
Abstract
Complement activity in mammalian serum is fundamentally based on three homologous components C3b, C4b and C5. During systemic infection, the gastrointestinal pathogen Salmonella enterica disseminates within host phagocytic cells but also extracellularly. Consequently, systemic Salmonella transiently confronts the complement system. We show here that the surface protease PgtE of S. enterica proteolytically cleaves C3b, C4b and C5 and that the expression of PgtE enhances bacterial resistance to human serum. Degradation of C3b was further enhanced by PgtE-mediated plasminogen activation.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Päivi Ramu, Rauna Tanskanen, Mikko Holmberg, Kaarina Lähteenmäki, Timo K. Korhonen, Seppo Meri,