Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050193 | FEBS Letters | 2008 | 7 Pages |
Abstract
The majority of drug-related toxicities are idiosyncratic, with little pathophysiological insight and mechanistic understanding. Pathway toxicology is an emerging field of toxicology in the post-genomic era that studies the molecular interactions between toxicants and biological pathways as a way to bridge this knowledge gap. Using two case studies – acetaminophen and p38 MAPK inhibitors – this review illustrates how a pathway-based perspective has advanced our understanding of compound and target-based toxicities. The advancement of pathway toxicology will be dependent on integrated applications of techniques from basic sciences and a fundamental understanding of the interdependence of multiple biological pathways in living organisms.
Keywords
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Authors
Jinghai J. Xu, Bart S. Hendriks, Jie Zhao, David de Graaf,