Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050238 | FEBS Letters | 2008 | 6 Pages |
Abstract
Mice lacking tob2, a member of the antiproliferative family genes, had decreased bone mass, and the number of osteoclasts differentiated from bone marrow cells was increased. Overexpression of Tob2 in stromal cells repressed vitamin D3-induced osteoclasts formation. Furthermore, expression of RANKL mRNA in stromal cells was increased in the absence of Tob2 and decreased in the presence of Tob2. Tob2 interacted with vitamin D3 receptor (VDR), which suggests its involvement in vitamin D3 receptor-mediated regulation of transcription. Because VDR regulates RANKL expression, our data suggest that Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with VDR.
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Authors
Rieko Ajima, Toru Akiyama, Michihiko Usui, Mitsuhiro Yoneda, Yutaka Yoshida, Takahisa Nakamura, Osamu Minowa, Masaki Noda, Sakae Tanaka, Tetsuo Noda, Tadashi Yamamoto,