Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050299 | FEBS Letters | 2006 | 5 Pages |
Abstract
To achieve maximal transcriptional activity in response to gp130 cytokines, Serine-727 (Ser-727) of Stat3 is phosphorylated. Ser-727 resides in the LPMSP motif, the only conserved sequence among the transcription activation domains of several STATs. We show here that in addition to Ser-727, other residues in this LPMSP motif are also required for Stat3 activity in response to cytokine signaling through regulation of Ser-727 phosphorylation and recruitment of the transcription co-activator CBP/p300 to the promoters of Stat3-target genes for transcription activation. Hence, we have demonstrated a critical role for the whole conserved LPMSP motif in JAK-STAT signaling.
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Authors
Wei Sun, Marylynn Snyder, David E. Levy, J. Jillian Zhang,