| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2050474 | FEBS Letters | 2007 | 5 Pages |
Abstract
We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation.Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of α-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs.By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.
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Authors
Marco Prunotto, Marc Bacchetta, Swaminathan Jayaraman, Marco Galloni, Guillaume Van Eys, Giulio Gabbiani, Marie-Luce Bochaton-Piallat,