Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050485 | FEBS Letters | 2007 | 6 Pages |
Abstract
Using an in vitro co-culture approach comprising cultured murine superior cervical ganglia and MC3T3-E1 osteoblast-like cells, we found that the addition of scorpion venom (SV) elicited neurite activation via intracellular Ca2+ mobilization and, after a lag period, osteoblastic Ca2+ mobilization. SV did not have any direct effect on the osteoblastic cells in the absence of neurites. The addition of an α1-adrenergic receptor (AR) antagonist, prazosin, dose-dependently prevented the osteoblastic activation that resulted as a consequence of neural activation by SV. These results demonstrate that osteoblastic activation occurred as a direct response to neuronal activation, which activation was mediated by α1-ARs in the osteoblastic cells.
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Authors
Koji Obata, Tadahide Furuno, Mamoru Nakanishi, Akifumi Togari,