Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050526 | FEBS Letters | 2009 | 7 Pages |
Abstract
Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 – the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.
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Authors
Ana Luísa Silva, Luísa Romão,