Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050552 | FEBS Letters | 2007 | 7 Pages |
Abstract
Overlooked until recently, mitochondrial protein phosphorylation is now emerging as a key post-translational mechanism in the regulation of mitochondrial functions. In particular, tyrosine phosphorylation represents a promising field to discover new mechanisms of bioenergetic regulation. Tyrosine kinases belonging to the Src kinase family have been observed in mitochondrial compartments, however their substrates are almost unknown.Here, we provide evidence that the flavoprotein of succinate dehydrogenase and aconitase are “in vitro” substrates of Fgr tyrosine kinase. Fgr phosphorylates flavoprotein of succinate dehydrogenase at Y535 and Y596 and aconitase at Y71, Y544 and Y665. The significance of these findings is discussed.
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Authors
Mauro Salvi, Nick A. Morrice, Anna Maria Brunati, Antonio Toninello,