| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2050562 | FEBS Letters | 2007 | 5 Pages |
ΔNp63α is exclusively expressed in stem cells and progenitor cells of the stratified epithelia. It promotes cell proliferation by antagonizing p53 and related TAp63/TAp73. Here, we report that specific desumoylation by SUMO protease SuPr-1 provides a fine-tuning mechanism for ΔNp63α repressor activity. We found that disrupting the sumoylation site compromised ΔNp63α repressor activity profoundly against TAp63γ and TAp73β-mediated transcription activation, but not to p53-mediated transcription. We further found that SuPr-1 specifically bound to sumoylated ΔNp63α and hydrolyzed SUMO. Consequently, SuPr-1 expression reduced ΔNp63α repressor activity to TAp63γ and TAp73β, whereas p53-mediated transactivation was unaffected. Collectively, these data suggest that SuPr-1-mediated ΔNp63α desumoylation elaborately regulates epithelial growth.
