Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050576 | FEBS Letters | 2007 | 5 Pages |
Abstract
The key transcription factor that regulates the cellular responses to hypoxia is hypoxia inducible factor-1 (HIF-1). The signaling mechanisms that regulate the hypoxic activation of HIF-1 are not fully understood. Our objective here was to test whether AMP-activated kinase (AMPK) was an upstream regulator of HIF-1. Our results show that AMPK is not required for the hypoxic activation of HIF-1. Interestingly, the AMPK inhibitor, Compound C, inhibits the hypoxic activation of HIF-1 independent of AMPK. Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS.
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Authors
Brooke M. Emerling, Benoit Viollet, Kathryn V. Tormos, Navdeep S. Chandel,