Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050588 | FEBS Letters | 2006 | 5 Pages |
Abstract
Patients suffering from Refsum disease have a defect in the α-oxidation pathway which results in the accumulation of phytanic acid in plasma and tissues. Our previous studies have shown that phytanic acid is also a substrate for the ω-oxidation pathway. With the use of specific inhibitors we now show that members of the cytochrome P450 (CYP450) family 4 class are responsible for phytanic acid ω-hydroxylation. Incubations with microsomes containing human recombinant CYP450s (Supersomes™) revealed that multiple CYP450 enzymes of the family 4 class are able to ω-hydroxylate phytanic acid with the following order of efficiency: CYP4F3A > CYP4F3B > CYP4F2 > CYP4A11.
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Authors
J.C. Komen, R.J.A. Wanders,