Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050630 | FEBS Letters | 2007 | 6 Pages |
Abstract
The deletion of the zwf gene encoding G6PDH activity led to restructuring of the carbon flux through central metabolism in Escherichia coli, though over-expression of this gene had only minor consequences for overall carbon flux. The modified carbon flux seen in the zwf deletion mutant enabled alternative routes of anabolic precursor formation and an adequate supply of NADPH synthesis via a modified TCA cycle to be generated so as to sustain growth rates comparable to the WT.
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Authors
Cécile Nicolas, Patrick Kiefer, Fabien Letisse, Jens Krömer, Stéphane Massou, Philippe Soucaille, Christoph Wittmann, Nic D. Lindley, Jean-Charles Portais,