Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050640 | FEBS Letters | 2007 | 7 Pages |
Abstract
Overexpression of TGFβ inducible early gene (TIEG1) mimics TGFβ action and induces apoptosis. In this study, we found that TIEG1 was significantly up-regulated during apoptosis induced by homoharringtonine or velcade. Overexpression of TIEG1 could induce apoptosis in K562 cells and promote apoptosis induced by HHT or velcade. TIEG1-induced apoptosis was shown to involve Bax and Bim up-regulation, Bcl-2 and Bcl-XL down-regulation, release of cytochrome c from mitochondria into the cytosol, activation of caspase 3 and disruption of the mitochondrial membrane potential (ΔΨm). We concluded that TIEG1 is a key regulator which induces and promotes apoptosis through the mitochondrial apoptotic pathway.
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Authors
Wei Jin, Genhong Di, Junjie Li, Ying Chen, Wenfeng Li, Jiong Wu, Tiewei Cheng, Ming Yao, Zhimin Shao,