Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050660 | FEBS Letters | 2008 | 8 Pages |
Abstract
Sterol regulatory element binding protein (SREBP)-1a is a transcription factor that is highly expressed in actively growing cells, and is involved in the biosynthesis of cholesterol, fatty acids and phospholipids. We have mapped the minimal human SREBP-1a promoter region to 75 bp upstream of the translation start site where we discovered a functional role for the 3 GC-boxes containing overlapping sites for the Sp1 and EGR-1 transcription factors. Intact SP1-binding sites are essential for promoter activity, whereas EGR-1 suppresses the transcription of the human SREBP-1a promoter. These results reveal a novel physiologically relevant transcriptional mechanism for the reciprocal regulation of the SREBP-1a expression.
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Authors
Ana Fernández-Álvarez, Gemma Tur, Gerardo López-Rodas, Marta Casado,