Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050782 | FEBS Letters | 2007 | 7 Pages |
Abstract
Pom121 is one of the integral membrane components of the nuclear pore complex (NPC) in vertebrate cells. Unlike rodent cells carrying a single POM121 gene, human cells possess multiple POM121 gene loci on chromosome 7q11.23, as a consequence of complex segmental-duplications in this region during human evolution. In HeLa cells, two “full-length” Pom121 are transcribed and translated by two distinct genetic loci. RNAi experiments showed that efficient depletion of both Pom121 proteins significantly reduces assembled NPCs on nuclear envelope. Pom121-depletion also induced clustering of NPCs, indicating its role on maintenance of NPC structure/organization.
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Authors
Tomoko Funakoshi, Kazuhiro Maeshima, Kazuhide Yahata, Sumio Sugano, Fumio Imamoto, Naoko Imamoto,