Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050784 | FEBS Letters | 2007 | 6 Pages |
Abstract
Survivin protein accomplishes two basic functions: cell cycle regulation and control of apoptosis. It is only expressed in G2/M phase and it influences rescue pathways in apoptosis-induced cells. Overexpression of constitutive active c-H-ras in HeLa, or induction of c-H-ras in a stable HeLaDiR cell line, led to sustained survivin expression in all cell cycle phases and even protected cells from drug induced apoptosis. siRNA-mediated silencing of survivin reversed this protection. Here we link the anti-apoptotic property of survivin to its cell cycle (in)dependent regulation via the activity of oncogenic c-H-ras.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Klaus W. Sommer, Chantal J. Rodgarkia-Dara, Claudia Schreiner, Klaus Holzmann, Georg Krupitza, Christa Cerni,