Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2050929 | FEBS Letters | 2007 | 7 Pages |
Abstract
T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation.
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Authors
Lotte Wieten, Femke Broere, Ruurd van der Zee, Elles Klein Koerkamp, Josée Wagenaar, Willem van Eden,