Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051147 | FEBS Letters | 2008 | 7 Pages |
Abstract
In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-κB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-κB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Tomohiro Koga, Takafumi Torigoshi, Satoru Motokawa, Taichiro Miyashita, Yumi Maeda, Minoru Nakamura, Atsumasa Komori, Yoshihiro Aiba, Takashi Uemura, Hiroshi Yatsuhashi, Hiromi Ishibashi, Katsumi Eguchi, Kiyoshi Migita,