Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051156 | FEBS Letters | 2008 | 8 Pages |
Abstract
Vascular smooth muscle cells (VSMC) have been isolated from male and female rat aorta and studied to assess their susceptibility to ultraviolet radiation-induced oxidative stress. Interestingly, a gender difference, in terms of reactive oxygen species production, was detected in both basal and irradiated VSMC. Namely, VSMC from male rats were more susceptible to radiation-induced stress and easier underwent apoptosis in comparison to cells from female rats. Conversely, the latter, in the same experimental conditions, clearly displayed signs of premature senescence. These results indicate that a sort of “gender memory” can be conserved in VMSC in primary culture.
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Authors
Walter Malorni, Elisabetta Straface, Paola Matarrese, Barbara Ascione, Rita Coinu, Silvia Canu, Paola Galluzzo, Maria Marino, Flavia Franconi,