Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051171 | FEBS Letters | 2008 | 4 Pages |
Abstract
In mitochondrial apoptosis, the formation of cytochrome c–cardiolipin complex ([CL-cyt c]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP), which compartmentalizes exclusively into mitochondria, undergoes a [CL-cyt c]-catalyzed bioactivation to nitric oxide (NO), inhibits peroxidase activity, and protects cells from apoptosis.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Detcho A. Stoyanovsky, Irina I. Vlasova, Natalia A. Belikova, Alexandr Kapralov, Vladimir Tyurin, Valerian E. Kagan,