| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2051279 | FEBS Letters | 2007 | 5 Pages |
Abstract
The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
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Authors
Daria Maria Monti, Nicola Montesano Gesualdi, Josef Matoušek, Franca Esposito, Giuseppe D’Alessio,