Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051285 | FEBS Letters | 2007 | 5 Pages |
Abstract
We investigate here the anti-angiogenic properties of the synthetic compound myo-inositol trispyrophosphate (ITPP). By increasing oxy-haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model. ITPP also markedly reduced tumor progression and angiogenesis in an experimental model of U87 glioma cell nodules grafted onto the CAM. These results point out the potential of ITPP for the development of a new class of anti-angiogenic and anti-cancer compounds.
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Authors
Gabin Sihn, Thomas Walter, Jean-Claude Klein, Isabelle Queguiner, Hiroshi Iwao, Claude Nicolau, Jean-Marie Lehn, Pierre Corvol, Jean-Marie Gasc,