Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051289 | FEBS Letters | 2007 | 6 Pages |
Abstract
NDRG1 is a hypoxia-inducible protein, whose modulated expression is associated with the progression of human cancers. Here, we reveal that NDRG1 is markedly upregulated in the cytoplasm and on the membrane in human hepatocellular carcinoma (HCC). We demonstrate further that hypoxic stress increases the cytoplasmic expression of NDRG1 in vitro, but does not result in its localization on the plasma membrane. However, grown within an HCC-xenograft in vivo, cells express NDRG1 in the cytoplasm and on the plasma membrane. In conclusion, hypoxia is a potent inducer of NDRG1 in HCCs, albeit requiring additional stimuli within the tumour microenvironment for its recruitment to the membrane.
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Authors
Sonja Sibold, Vincent Roh, Adrian Keogh, Peter Studer, CĂ©line Tiffon, Eliane Angst, Stephan A. Vorburger, Rosemarie Weimann, Daniel Candinas, Deborah Stroka,