Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051376 | FEBS Letters | 2007 | 8 Pages |
Abstract
The role of the nuclear receptor FXR in adaptive thermogenesis was investigated using FXR-deficient mice. Despite elevated serum bile acid concentrations and increased mRNA expression profiles of thermogenic genes in brown adipose tissue, FXR-deficiency did not alter energy expenditure under basal conditions. However, FXR-deficiency accelerated the fasting-induced entry into torpor in a leptin-dependent manner. FXR-deficient mice were also extremely cold-intolerant. These altered responses may be linked to a more rapid decrease in plasma concentrations of metabolic fuels (glucose, triglycerides) thus impairing uncoupling protein 1-driven thermogenesis. These results identify FXR as a modulator of energy homeostasis.
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Authors
Bertrand Cariou, Emmanuel Bouchaert, Mouaadh Abdelkarim, Julie Dumont, Sandrine Caron, Jean-Charles Fruchart, Rémy Burcelin, Folkert Kuipers, Bart Staels,