Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051510 | FEBS Letters | 2007 | 4 Pages |
Abstract
This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30 min, compared to 30 h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.
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Authors
Sophie Rousset, Julien Mozo, Geneviève Dujardin, Yalin Emre, Sandrine Masscheleyn, Daniel Ricquier, Anne-Marie Cassard-Doulcier,