Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051577 | FEBS Letters | 2007 | 6 Pages |
Abstract
Expression of CUB domain containing protein 1 (CDCP1) is upregulated in carcinoma cells. We quantitated CDCP1 gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCP1 gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface.
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Authors
Sara E. Perry, Philip Robinson, Alan Melcher, Philip Quirke, Hans-Jörg Bühring, Graham P. Cook, G. Eric Blair,