Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051617 | FEBS Letters | 2007 | 6 Pages |
Abstract
Telomerase is a multimolecular complex of reverse transcriptase, RNA template, and regulatory proteins. It has two known functions: catalysis of the addition of [TTAGGG] repeats to telomeric DNA and the activation of various genes controlling cell proliferation. The possible coordination of these two functions is a key issue in understanding the growth of cancer cells. We report long-term changes to this complex system, as shown by specific data analysis methods. We show that the dynamics of the two functions of telomerase are tightly linked, with a change in predominant function every 13–14 weeks. The conservative behavior of this dynamic system probably accounts for the persistent proliferation of cancer cells.
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Authors
Claire Wolfrom, Olivier C. Martin, Michel Laurent, Jean Deschatrette,