Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051638 | FEBS Letters | 2006 | 6 Pages |
Abstract
Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase α chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage.
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Authors
Ingrid Miller, Manfred Gemeiner, Bernd Gesslbauer, Andreas Kungl, Christina Piskernik, Susanne Haindl, Silvia Nürnberger, Soheyl Bahrami, Heinz Redl, Andrey V. Kozlov,