Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051655 | FEBS Letters | 2006 | 5 Pages |
Abstract
Uncoupling protein-3 (UCP3) has been suggested to protect against lipid-induced oxidative damage. Therefore, we studied intramuscular lipid peroxide levels and high-fat diet induced alterations in muscle lipid metabolism of UCP3-ablated mice.UCP3−/− mice showed ∼3-fold higher levels of intramuscular lipid peroxides upon standard chow feeding, compared to wild-type littermates. Remarkably, this difference was no longer apparent on the high-fat diet. However, upon high-fat feeding, intramuscular triacylglycerol levels were ∼50% lower in UCP3−/− mice, in comparison to UCP3+/+ animals. Succinate dehydrogenase activity, and total protein content of the muscle fatty acid transporter FAT/CD36 were however similar between UCP3−/− and UCP3+/+ mice.
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Authors
Joris Hoeks, Matthijs K.C. Hesselink, Wim Sluiter, Gert Schaart, Jodil Willems, Alastair Morrisson, John C. Clapham, Wim H.M. Saris, Patrick Schrauwen,