Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051798 | FEBS Letters | 2005 | 5 Pages |
Abstract
Hypoxia inducible factor-1α (HIF-1α) is a central component of the cellular responses to hypoxia. Hypoxic conditions result in stabilization of HIF-1α and formation of the transcriptionally active HIF-1 complex. It was suggested that mammalian ARD1 acetylates HIF-1α and thereby enhances HIF-1α ubiquitination and degradation. Furthermore, ARD1 was proposed to be downregulated in hypoxia thus facilitating the stabilization of HIF-1α. Here we demonstrate that the level of human ARD1 (hARD1) protein is not decreased in hypoxia. Moreover, hARD1 does not acetylate and destabilize HIF-1α. However, we find that hARD1 specifically binds HIF-1α, suggesting a putative, still unclear, connection between these proteins.
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Authors
Thomas Arnesen, Xianguo Kong, Rune Evjenth, Darina Gromyko, Jan Erik Varhaug, Zhao Lin, Nianli Sang, Jaime Caro, Johan R. Lillehaug,