Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051839 | FEBS Letters | 2006 | 8 Pages |
Abstract
Integrins are type I heterodimeric (α/β) cell adhesion molecules. They trigger cell-signaling by recruiting cytosolic molecules to their cytoplasmic tails. Integrin α cytoplasmic tail contributes towards integrin function specificity, an important feature of integrins having different α subunits but sharing the same β subunit. Herein, we show that the src family kinase Hck co-capped selectively with leukocyte integrin αMβ2 but not αLβ2 or αXβ2. This was disrupted when the αM cytoplasmic tail was substituted with that of αL or αX. Co-capping was recovered by αL or αX cytoplasmic tail truncation or forced separation of the α and β cytoplasmic tails via salt-bridge disruption.
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Authors
Ren-Hong Tang, S.K. Alex Law, Suet-Mien Tan,