Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051901 | FEBS Letters | 2006 | 6 Pages |
Abstract
In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high-resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available prediction methods should only be used as guidelines to provide a basis of experimental strategies for the elucidation of the membrane topology.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Gábor E. Tusnády, Balázs Sarkadi, István Simon, András Váradi,