| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2051904 | FEBS Letters | 2006 | 7 Pages |
Abstract
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.
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Authors
Christopher L. Reyes, Andrew Ward, Jodie Yu, Geoffrey Chang,