Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051972 | FEBS Letters | 2005 | 8 Pages |
Abstract
In this study, we investigated the influence of inorganic lead (Pb(II)), an environmental pollutant having nephrotoxic action, on the focal adhesion (FA) organization of a rat kidney epithelial cell line (NRK-52E). In particular, we evaluated the effects of the metal on the recruitment of paxillin, focal adhesion kinase, vinculin and cytoskeleton proteins at the FAs complexes. We provided evidences that, in proliferating NRK-52E cell cultures, low concentrations of Pb(II) affect the cell adhesive ability and stimulate the disassembly of FAs, thus inhibiting the integrin-activated signalling. These effects appeared to be strictly associated to the Pb-induced arrest of cell cycle at G0/G1 phase also proved in this cell line.
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Authors
Roberta Giuliani, Francesca Bettoni, Daria Leali, Fausta Morandini, Pietro Apostoli, Piergiovanni Grigolato, Bruno Mario Cesana, Maria Francesca Aleo,