Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2051983 | FEBS Letters | 2007 | 9 Pages |
Abstract
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
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Authors
Leslie Bailey, Åsa Gylfe, Charlotta Sundin, Sandra Muschiol, Mikael Elofsson, Peter Nordström, Birgitta Henriques-Normark, Raimond Lugert, Anders Waldenström, Hans Wolf-Watz, Sven Bergström,