Article ID Journal Published Year Pages File Type
2052117 FEBS Letters 2006 5 Pages PDF
Abstract

The very first member of K+ channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically.OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183 ± 3 nM but did not affect any of the other channels.

Related Topics
Life Sciences Agricultural and Biological Sciences Plant Science
Authors
, , , , , , ,