| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2052217 | FEBS Letters | 2006 | 6 Pages |
Abstract
Osteoblastic differentiation is an essential part of bone formation. Dimethyl sulfoxide (DMSO) is a water miscible solvent that is used extensively for receptor ligands in osteoblast studies. However, little is known about its effects on osteoblastogenic precursor cells. In this study, we have used a murine preosteoblast cell line MC3T3-E1 cells to demonstrate that DMSO effectively induces osteoblastic differentiation of MC3T3-E1 cells via the activation of Runx2 and osterix and is dependent upon the protein kinase C (PKC) pathways. We further demonstrated that prolonged activation of PKC pathways is sufficient to induce osteoblastic differentiation, possibly via the activation of PKD/PKCĪ¼.
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Authors
W.M.W. Cheung, W.W. Ng, A.W.C. Kung,