Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2052245 | FEBS Letters | 2006 | 6 Pages |
Abstract
The effect of dehydroepiandrosterone (DHEA) on pancreatic islet function of aged rats, an animal model with impaired glucose-induced insulin secretion, was investigated. The following parameters were examined: morphological analysis of endocrine pancreata by immunohistochemistry; protein levels of insulin receptor, IRS-1, IRS-2, PI 3-kinase, Akt-1, and Akt-2; and static insulin secretion in isolated pancreatic islets. Pancreatic islets from DHEA-treated rats showed an increased β-cell mass accompanied by increased Akt-1 protein level but reduced IR, IRS-1, and IRS-2 protein levels and enhanced glucose-stimulated insulin secretion. The present results suggest that DHEA may be a promising drug to prevent diabetes during aging.
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Authors
Mayrin C. Medina, Lílian C. Souza, Luciana C. Caperuto, Gabriel F. Anhê, Angélica M. Amanso, Vicente P.A. Teixeira, Silvana Bordin, Ângelo R. Carpinelli, Luiz R.G. Britto, Renato L. Barbieri, Maria I. Borella, Carla R.O. Carvalho,